BiochemistrybioRxiv
A Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate
M. J. McBride, M. A. Nair, D. Sil…·J. M. Bollinger
The paper characterizes a substrate-triggered μ-peroxodiiron(III) intermediate in the enzyme BesC, showing it initiates oxidative fragmentation by abstracting hydrogen from C4 and allowing substrate dissociation.
DOI 10.1021/acs.biochem.1c00774