TIGIT is upregulated by HIV-1 infection and marks a highly functional adaptive and mature subset of natural killer cells
E. Vendrame, C. Seiler, T. Ranganath, N. Q. Zhao, R. Vergara, M. Alary, A. C. Labbe, F. Guedou, J. Poudrier, S. Holmes, M. Roger, C. A. Blish
This study shows that TIGIT is upregulated on NK cells in untreated HIV+ individuals and marks a functional, mature NK cell subset with enhanced responses to HIV-infected targets.
bioRxiv · Sep 10, 2019Immunology