Author

M. Aldea

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 4 Approach:experimental assay· 4 Organism:yeast· 4 Assay:bulk RNA-seq· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. Perez· 2 shared D. F. Moreno· 2 shared A. Csikasz-Nagy· 1 shared A. Malliri· 1 shared A. Marinello· 1 shared A. Viros· 1 shared B. Besse· 1 shared B. Gonzalez· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

A. P. Perez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRASG12D-driven non-small cell lung cancer

W. J. McDaid, L. Wilson, H. Adderley, M. J. Baker, J. Searle, L. Ginn, T. Budden, M. Aldea, A. Marinello, J. Aredo, A. Viros, B. Besse, H. A. Wakelee, F. Blackhall, C. R. Lindsay, A. Malliri

This study compares KRASG12C and KRASG12D mutant NSCLC models, finding that KRASG12D relies more on the PI3K-AKT-mTOR pathway, suggesting tailored combination therapies.

bioRxiv · Sep 20, 2023Cancer Biology

Transcriptomic balance and optimal growth are determined by cell size

P. J. Vidal, A. P. Perez, M. Aldea

The paper shows that cell size affects growth and transcriptome balance in yeast and mouse liver cells, with maximal growth occurring at a critical size.

bioRxiv · Nov 8, 2022Cell Biology

Exploring the Regulation of Cdc42 Stability and Turnover in Yeast

B. Gonzalez, M. Aldea, P. J. Cullen

This paper identifies high temperature-induced degradation of yeast Cdc42p via ubiquitin ligase and chaperones, revealing a tradeoff between mating sensitivity and cellular fitness.

bioRxiv · Sep 30, 2022 · PreprintCell Biology

Stress granules display bistable dynamics modulated by Cdk

G. Yahya, A. P. Perez, M. B. Mendoza, E. Parisi, D. F. Moreno, C. Gallego, M. Aldea

The paper shows stress granules in yeast exhibit bistable dynamics regulated by Cdk through mutual inhibition between SGs and Cdc28.

bioRxiv · May 8, 2020Cell Biology

Proteostasis collapse halts G1 progression and delimits replicative lifespan

D. F. Moreno, K. Jenkins, S. Morlot, G. Charvin, A. Csikasz-Nagy, M. Aldea

This study shows that proteostasis collapse in yeast leads to G1 arrest and limits replicative lifespan through chaperone-dependent mechanisms.

bioRxiv · May 24, 2019 · PreprintCell Biology