G. Charvin

HeatChips: A versatile, low-cost and microscopy-compatible heating system for microfluidic devices

HeatChips provides a low-cost, microscopy-compatible heating system for microfluidic devices that maintains homogeneous temperature control.

Distinct mechanisms underlie H2O2 sensing in C. elegans head and tail

The paper shows that C. elegans head and tail neurons use distinct mechanisms to sense H2O2, involving different receptors but shared peroxiredoxin PRDX-2.

DetecDiv, a generalist deep-learning platform for automated cell division tracking and survival analysis

DetecDiv automates cell division tracking and survival analysis using deep learning, enabling high-throughput studies of yeast cell dynamics and stress responses.

Nuclear Pore Complex Acetylation Regulates mRNA Export and Cell Cycle Commitment in Budding Yeast

The paper shows that Esa1 acetylates Nup60 to regulate mRNA export and cell cycle progression in budding yeast.

Specialization of chromatin-bound nuclear pore complexes promotes yeast aging

This study shows that DNA circles in yeast cells alter NPC composition, leading to aging by triggering NPC specialization.

A trade-off between stress resistance and tolerance underlies the adaptive response to hydrogen peroxide

This study identifies a trade-off between stress resistance and tolerance in budding yeast and bacteria during the response to hydrogen peroxide, showing that reducing resistance increases tolerance.

Increased levels of the mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The paper shows that overexpressing Mia40 reduces toxic polyQ protein aggregates in yeast and human cells by competing for chaperone and proteasome resources.

Monitoring single-cell dynamics of entry into quiescence during an unperturbed lifecycle

The paper develops a microfluidic device to track single-cell dynamics during yeast quiescence, revealing fate divergence and stochastic cytosolic glass transitions.

Proteostasis collapse halts G1 progression and delimits replicative lifespan

This study shows that proteostasis collapse in yeast leads to G1 arrest and limits replicative lifespan through chaperone-dependent mechanisms.

Multiple inputs ensure yeast cell size homeostasis during cell cycle progression

The paper shows that yeast cell size homeostasis is maintained through multiple mechanisms, including G2/M regulation, not just G1-specific controls.