Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells
A. Vrynas, S. Bazban-Shotorbani, S. Arfan, K. Satia, B. Cunningham, G. Sagindykova, M. Ashna, A. Zhang, D. Visan, A. Chen, M. Carter, T. Matthews-Palmer, F. Blackhall, K. Simpson, C. Dive, , S. H. Au
This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.
bioRxiv · Apr 17, 2024Cancer Biology