K. Simpson

Circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations that activate endothelial and immune cells

This study shows circulating tumor cells shed shearosome extracellular vesicles in capillary bifurcations, which activate endothelial and immune cells and contribute to pre-metastatic niche formation.

Microfabrication-based engineering of biomimetic dentin-like constructs to simulate dental aging

This study develops a microfabricated biomimetic dentin model to simulate dental aging and test oral biofilm formation.

PAK1-dependant mechanotransduction enables myofibroblast nuclear adaptation and chromatin organisation during fibrosis

The paper identifies PAK1-dependent mechanotransduction as critical for myofibroblast nuclear adaptation and chromatin organization during fibrosis, showing its impact on gene regulation and disease progression.

Systematic Nature Positive Markets

The paper argues that current biodiversity credit markets fail to prevent ecosystem loss and proposes defining credits by site irreplaceability to ensure effective and equitable conservation outcomes.

Serum CSF1 levels are elevated in patients following partial hepatectomy and acetaminophen induced acute liver failure: Reanalysis of previous data

This study reanalyzes previous data showing elevated serum CSF1 levels after partial hepatectomy and in ALF patients, with higher levels in non-survivors.

Targeting of TP53-independent cell cycle checkpoints overcomes FOLFOX resistance in Metastatic Colorectal Cancer

This study identifies FOLFOX resistance in metastatic CRC through cell cycle checkpoint dysregulation and shows that targeting these checkpoints can resensitize resistant organoids to FOLFOX.

Epithelial cell biomarkers are predictive of response to biologic agents in Crohn's disease

The paper shows that ileal microvillar length (MVL) predicts response to biologics ustekinumab and vedolizumab in Crohn's disease, with combined biomarkers improving prediction accuracy.

SOX9 is required for kidney fibrosis and regulates NAV3 to control renal myofibroblast function in mice and humans

This study identifies SOX9 as essential for kidney fibrosis and shows it regulates NAV3 to control myofibroblast function in mice and humans.

Pre-warming before general anesthesia with isoflurane delays the onset of hypothermia in rats

This study shows pre-warming rats before isoflurane anesthesia delays hypothermia onset, with PW40 being most effective.

Functional diversification enabled grassy biomes to fill global climate space

The paper maps global grassy biomes and identifies key traits and lineages driving their distribution across climates.

MicroRNAs as potential therapeutics to enhance chemosensitivity in advancedprostate cancer

This study identifies microRNA mimics that enhance taxane-induced apoptosis in CRPC cell lines, suggesting potential therapeutic use to improve chemosensitivity.