Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung
M. Aufiero, N. Shlezinger, M. Gjonbalaj, K. A. M. Mills, A. Ballabio, T. M. Hohl
This study shows that TFEB and TFE3 activation by Dectin-1/CARD9 in myeloid phagocytes is not essential for anti-Aspergillus activity in the lung despite promoting macrophage fungicidal activity in vitro.
bioRxiv · Jun 13, 2023 · PreprintImmunology