Author

S. Dhingra

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Bioengineering· 2 Immunology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:fungi (other)· 2

Frequent Co-Authors

R. A. Cramer· 3 shared A. Banuelos· 2 shared A. Delaidelli· 2 shared C. L. Mackall· 2 shared E. Sotillo· 2 shared I. L. Weissman· 2 shared J. Huang· 2 shared J. Theruvath· 2 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersMicrobiology

R. A. Cramer

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Code for Collagen Folding Deciphered

J.-D. Malcor, N. Ferruz, S. Romero-Romero, S. Dhingra, V. Sagar, A. A. Jalan

This study identifies interchain electrostatic interactions as critical for collagen triple helix folding, showing their conservation across domains of life and viruses.

bioRxiv · Feb 24, 2024 · PreprintBiochemistry

Role of the osaA gene in Aspergillus fumigatus development, secondary metabolism and virulence.

A. Dabholkar, S. Pandit, R. Devkota, S. Dhingra, S. Lorber, O. Puel, A. M. Calvo

This study investigates the role of the osaA gene in Aspergillus fumigatus, showing its impact on growth, conidiation, cell wall integrity, secondary metabolism, and virulence.

bioRxiv · Dec 21, 2023 · PreprintMicrobiology

Engineered CD47 protects T cells for enhanced antitumor immunity

S. A. Yamada-Hunter, J. Theruvath, B. J. McIntosh, K. A. Freitas, M. T. Radosevich, A. Leruste, S. Dhingra, N. Martinez-Velez, P. Xu, A. Delaidelli, M. H. Desai, Z. Good, L. Labanieh, C. W. Mount, Y. Chen, , C. L. Mackall

This paper engineers a CD47 variant to protect T cells from macrophage clearance, enhancing antitumor efficacy by combining T cell and macrophage activation.

bioRxiv · Jun 20, 2023 · PreprintBioengineering

Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity

M. R. James, M. Aufiero, E. M. Vesely, S. Dhingra, K.-W. Liu, T. M. Hohl, R. A. Cramer

This study shows that loss of cytochrome c in Aspergillus fumigatus reduces susceptibility to ROS-induced cell death and host leukocyte killing.

bioRxiv · Jun 7, 2023 · PreprintMicrobiology

A multi-omics analysis of glioma chemoresistance using a hybrid microphysiological model of glioblastoma

S. Shojaei, J. Basso, M. Amereh, J. Alizadeh, T. Dehesh, S. D. S. Rosa, C. Clark, M. Hassan, M. Tomczyk, L. Cole, G. Hatch, V. Dolinsky, C. Pasco, D. Schibli, S. Dhingra, , M. Akbari

This study uses a hybrid microphysiological model to analyze glioma chemoresistance and identifies molecular changes associated with resistance mechanisms.

bioRxiv · Oct 29, 2022 · PreprintBioengineering

Role of molecular polymorphism in defining tau filament structures in neurodegenerative diseases

X. Xiang, T. Arakhamia, Y. Carlomagno, S. Dhingra, M. Thierry, M. DeTure, C. N. Cook, D. W. Dickson, L. Petrucelli, A. Fitzpatrick

This study determines the structure of twisted tau filaments in progressive supranuclear palsy and compares them to tau folds in corticobasal degeneration, identifying molecular polymorphism as a factor in filament morphology.

bioRxiv · May 24, 2021 · PreprintBiophysics

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

J. Theruvath, M. Menard, B. A. Smith, M. H. Linde, G. Coles, W. Wu, L. Kiru, A. Delaidelli, J. L. Silberstein, A. Banuelos, S. Dhingra, E. Sotillo, S. Heitzeneder, A. Tousley, J. Lattin, , R. G. Majzner

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

bioRxiv · Mar 19, 2021 · PreprintImmunology

MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus

X. Wang, A. K. Caffrey-Carr, K.-w. Liu, V. Espinosa, W. Croteau, S. Dhingra, A. Rivera, R. A. Cramer, J. J. Obar

This study shows MDA5 is essential for host resistance against Aspergillus fumigatus through type I and III interferon signaling and antifungal neutrophil activity.

bioRxiv · Jul 6, 2020Immunology

A Ssd1 homolog impacts trehalose and chitin biosynthesis and contributes to virulence in Aspergillus fumigatus

A. Thammahong, S. Dhingra, K. M. Bultman, J. D. Kerkaert, R. A. Cramer

This study identifies SsdA as a key regulator of trehalose and cell wall biosynthesis in A. fumigatus, impacting virulence in a murine infection model.

bioRxiv · Mar 31, 2019Microbiology