R. A. Cramer

The Cystic Fibrosis treatment, Trikafta, affects growth, viability, and cell wall of Aspergillus fumigatus biofilms

This study shows Trikafta reduces A. fumigatus biofilm biomass, viability, and metabolic activity, while increasing susceptibility to antifungal drugs.

Aspergillus fumigatus cytochrome c impacts conidial survival during sterilizing immunity

This study shows that loss of cytochrome c in Aspergillus fumigatus reduces susceptibility to ROS-induced cell death and host leukocyte killing.

Post-Influenza Environment Reduces Aspergillus fumigatus Conidia Clearance and Facilitates Invasive Aspergillosis In Vivo

This study shows that influenza virus infection impairs neutrophil and monocyte function, reducing Aspergillus fumigatus conidia clearance and increasing invasive aspergillosis in mice.

Intestinal Bacteroides Modulates Systemic Inflammation and the Microbial Ecology in a Mouse Model of CF: Evidence for Propionate and other Short Chain Fatty Acids Reducing Systemic Inflammatory Cytokines

This study shows that Bacteroides in CF patients reduces systemic inflammation via propionate and alters microbial ecology in a mouse model of CF.

Host lung environment limits Aspergillus fumigatus germination through a SskA-dependent signaling response

The paper identifies a SskA-dependent signaling pathway that limits Aspergillus fumigatus germination in the host lung environment, enhancing disease initiation and inflammation.

An Alanine Aminotransferase is Required for Polysaccharide Regulation and Resistance of Aspergillus fumigatus Biofilms to Echinocandin Treatment

This study shows that alanine aminotransferase AlaA is essential for A. fumigatus biofilm formation and resistance to echinocandin antifungals, with its inhibition increasing drug susceptibility.

Aspergillus fumigatus In-Host HOG pathway mutation for Cystic Fibrosis Lung Microenvironment Persistence

This paper identifies a unique Pbs2 MAPKK allele in Aspergillus fumigatus isolates from CF patients that enables lung persistence by enhancing osmotic stress response in low oxygen but reducing oxidative stress resistance in standard conditions.

Antifungal activity of Propranolol against Fusarium keratitis isolates from the Mycotic Ulcer Treatment Trial (MUTT) and the United States.

This study evaluates the antifungal activity of propranolol and its enantiomers against Fusarium keratitis isolates and Aspergillus fumigatus, finding fungicidal effects and reduced MIC with natamycin.

A heterogeneously expressed gene family modulates biofilm architecture and hypoxic growth of Aspergillus fumigatus

This paper identifies a gene family in Aspergillus fumigatus that modulates biofilm architecture and hypoxic growth, with potential applications in clinical and industrial settings.

Strain specific persistence in the murine lung of Aspergillus fumigatus conidia causes an Allergic Broncho-Pulmonary Aspergillosis-like disease phenotype

This study identifies an A. fumigatus strain, W72310, that persists in the mouse lung and causes ABPA-like disease without significant hyphal growth.

MDA5 is an essential vita-PAMP sensor necessary for host resistance against Aspergillus fumigatus

This study shows MDA5 is essential for host resistance against Aspergillus fumigatus through type I and III interferon signaling and antifungal neutrophil activity.

A Ssd1 homolog impacts trehalose and chitin biosynthesis and contributes to virulence in Aspergillus fumigatus

This study identifies SsdA as a key regulator of trehalose and cell wall biosynthesis in A. fumigatus, impacting virulence in a murine infection model.

Characterizing the pathogenic, genomic, and chemical traits of Aspergillus fischeri, a close relative of the major human fungal pathogen Aspergillus fumigatus

This study compares Aspergillus fischeri and Aspergillus fumigatus to understand differences in pathogenicity, finding A. fischeri is less virulent, grows slower under stress, and has divergent secondary metabolism.