Author

A. Ballabio

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Esposito· 2 shared G. Napolitano· 2 shared J. Monfregola· 2 shared A. Agrawal· 1 shared A. Jha· 1 shared A. Ng· 1 shared B. A. Appleton· 1 shared C. Di Malta· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. Esposito

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Dectin-1/CARD9-induction of the TFEB and TFE3 gene network is dispensable for phagocyte anti-Aspergillus activity in the lung

M. Aufiero, N. Shlezinger, M. Gjonbalaj, K. A. M. Mills, A. Ballabio, T. M. Hohl

This study shows that TFEB and TFE3 activation by Dectin-1/CARD9 in myeloid phagocytes is not essential for anti-Aspergillus activity in the lung despite promoting macrophage fungicidal activity in vitro.

bioRxiv · Jun 13, 2023 · PreprintImmunology

Structural basis for mTORC1-dependent regulation of the lysosomal and autophagic transcription factor TFEB

Z. Cui, G. Napolitano, M. E. G. de Araujo, A. Esposito, J. Monfregola, L. Huber, A. Ballabio, J. H. Hurley

This paper determines the structural basis of mTORC1-dependent phosphorylation of TFEB using cryo-EM, revealing how TFEB is presented to mTORC1 for phosphorylation through a unique RagC GDP-dependent mechanism.

bioRxiv · Sep 12, 2022 · PreprintCell Biology

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

J. Goodwin, W. G. Walkup, K. Hooper, T. Li, C. Kishi-Itakura, A. Ng, T. Lehmberg, A. Jha, S. Kommineni, K. Fletcher, J. Garcia-Fortanet, Y. Fan, Q. Tang, M. Wei, A. Agrawal, , L. O. Murphy

bioRxiv · Feb 22, 2021Cell Biology

mTOR-dependent phosphorylation controls TFEB nuclear export

G. Napolitano, A. Esposito, H. Choi, V. Benedetti, M. Matarese, C. Di Malta, J. Monfregola, D. L. Medina, J. Lippincott-Schwartz, A. Ballabio

This study identifies mTOR-dependent phosphorylation of TFEB as a mechanism controlling its nuclear export and activity during nutrient re-feeding.

bioRxiv · Jun 5, 2018Cell Biology