ImmunologybioRxiv
The interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond
M. B. Geeson, J. C. Hsiao, L. P. Tsamouri…·D. A. Bachovchin
This study identifies a transient disulfide bond between NLRP1 and oxidized TRX1, revealing how NLRP1 senses cellular redox state to regulate inflammasome formation.
DOI 10.1016/j.chembiol.2023.12.012