Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity
M. Baars, T. Douma, D. R. Simeonov, D. R. Myers, S. Banerjee, K. Kulhanek, S. Zwakenberg, M. P. Baltissen, S. de Roock, F. van Wijk, M. Vermeulen, A. Marson, J. P. Roose, Y. Vercoulen
The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.
bioRxiv · Nov 8, 2019Immunology