F. van Wijk

Compartment-driven imprinting of intestinal CD4 (regulatory) T cells in inflammatory bowel disease and homeostasis

The paper examines CD4 T cell changes in inflammatory bowel disease, finding compartment-specific transcriptional programming driven by regulators like ARID4B and SATB1, with epithelial translocation dampening pro-inflammatory responses.

Human regulatory T-cells locally differentiate and are functionally heterogeneous within the inflamed arthritic joint

This study identifies functional heterogeneity in human regulatory T-cells within inflamed arthritic joints using single-cell sequencing and flow cytometry.

Compartmentalization and persistence of dominant (regulatory) T cell clones indicates antigen skewing in juvenile idiopathic arthritis

The paper identifies persistent, antigen-specific T cell clones in JIA joints and circulation, suggesting antigen-driven expansion of both Tregs and Teffector cells.

Functional Specialization of Specific DC Subsets in the Synovial Fluid of JIA Patients

This study identifies functional specialization of dendritic cell subsets in synovial fluid of JIA patients, showing cDC2 and monocytes are pro-inflammatory while cDC1 remains quiescent.

Epigenetic changes in autoimmune monocytes contribute to disease and can be targeted by JAKinhibition

The paper investigates epigenetic changes in monocytes from JIA patients and shows JAK inhibition can reverse disease-related gene expression.

Human placental bed transcriptomic profiling reveals inflammatory activation of endothelial cells in preeclampsia

The paper identifies inflammatory activation of endothelial cells in preeclampsia through transcriptomic profiling and systemic biomarker analysis.

Conserved human effector Treg signature is reflected in transcriptomic and epigenetic landscape

The paper identifies a conserved human effector Treg signature through transcriptomic and epigenetic analysis, showing overlap with tumor-infiltrating Treg and environment-driven adaptations.

Antigen-driven PD1+Tox+Eomes+ and PD1+Tox+BHLHE40+ synovial T lymphocytes regulate chronic inflammation in situ

The paper identifies distinct subpopulations of synovial T lymphocytes in JIA patients using single-cell RNA-sequencing and shows their roles in regulating chronic inflammation.

Dysregulated RASGRP1 expression through RUNX1 mediated transcription promotes autoimmunity

The paper shows that reduced RASGRP1 expression, regulated by RUNX1, contributes to autoimmunity by impairing T cell function and increasing inflammation.

Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like features

This study identifies a distinct transcriptional profile of uterine regulatory T cells at the maternal-fetal interface, showing features similar to tumor-infiltrating Tregs.