Temporal resolution of global gene expression and DNA methylation changes in the final phases of reprogramming towards induced pluripotency.
M. Bartoccetti, X. Luo, B. van der Veer, R. Khoueiry, A. Janiszewski, J. Xu, C. Verfaillie, V. Pasque, B. Thienpont, K. P. Koh
This study identifies sequential activation of Tet1 and Oct4 during iPSC reprogramming, revealing distinct DNA demethylation waves and epigenetic dynamics critical for generating high-quality iPSCs.
bioRxiv · Feb 13, 2019 · PreprintCell Biology