Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing
Z. G. Moreland, F. Jiang, C. Aguilar, M. Barzik, R. Gong, A. Shams, C. Faaborg-Andersen, J. C. Werth, R. Harley, D. C. Sutton, S. M. Cole, A. Parker, S. Morse, E. Wilson, Y. Takagi, , J. E. Bird
This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.
bioRxiv · Jul 9, 2021 · PreprintCell Biology