E. Wilson

FoxA1/2-dependent epigenomic reprogramming drives lineage switching in lung adenocarcinoma

This study shows FoxA1/2 reprogram the epigenome of NKX2-1-negative lung adenocarcinoma to drive a gastric lineage switch through DNA demethylation and regulatory element activation.

Genes associated with fitness and disease severity in the pan-genome of mastitis-associated Escherichia coli

This study identifies accessory genes in mastitis-associated E. coli linked to disease severity and competitive fitness using genome-wide association and in vivo competition assays.

GBMdeconvoluteR accurately infers proportions of neoplastic and immune cell populations from bulk glioblastoma transcriptomics data

This paper develops GBMdeconvoluteR, a tool to accurately infer neoplastic and immune cell proportions in bulk glioblastoma RNAseq data, validated against imaging mass cytometry.

Decreasing the flexibility of the TELSAM-target protein linker and omitting the cleavable fusion tag improves crystal order and diffraction limits

This study shows that rigidifying the TELSAM-target protein linker and removing the SUMO tag improves crystal diffraction resolution.

Cardiac contraction and relaxation are regulated by beta 1 adrenergic receptor generated cAMP pools at distinct membrane locations

The paper shows that beta 1 adrenergic receptor-generated cAMP pools at distinct membrane locations regulate cardiac contraction and relaxation through different PKA targets.

Serotyping Salmonella Enteritidis and Typhimurium Using Whole Cell Matrix Assisted Laser Desorption Ionization - Time of Flight Mass Spectrometry (MALDI-TOF MS) through Multivariate Analysis and Artificial Intelligence

This study uses MALDI-TOF MS and AI to accurately serotype Salmonella strains, achieving 100% correct identification of Enteritidis, Typhimurium, and other serovars.

Design, development, and preliminary assessment of a novel peripheral intravenous catheter aimed at reducing early failure rates

This paper designs a novel peripheral intravenous catheter (FloRamp) to reduce early failure rates and reports preliminary results from animal testing showing reduced occlusion and lower phlebitis scores.

Glioma-BioDP: Database for Visualization of Molecular Profiles to Improve Prognosis of Brain Cancer

Glioma-BioDP provides a web tool for exploring RNA and protein expression profiles in low- and high-grade gliomas to aid in prognosis and treatment personalization.

Meta-analysis on reporting practices as a source of heterogeneity in in vitro cancer research

This study analyzes reporting practices in in vitro glioblastoma research and finds significant heterogeneity in methodological reporting affecting reproducibility.

Increased microbial diversity and decreased prevalence of common pathogens in the gut microbiomes of wild turkeys compared to domestic turkeys

This study compares the gut microbiota of wild and domestic turkeys, finding higher microbial diversity and lower prevalence of common pathogens in wild turkeys.

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

TRIOBP promotes bidirectional radial stiffness gradients within the organ of Corti

The paper uses PFT-AFM to map stiffness gradients in cochlear epithelium, showing TRIOBP deficiency alters radial stiffness gradients and affects hearing.

A link between zinc uptake, bile salts, and a capsule required for virulence of a mastitis-associated extraintestinal pathogenic Escherichia coli strain

This study shows that the MAEC strain M12's virulence depends on its capsule, which may interfere with zinc homeostasis in the presence of bile salts.

A molecular atlas of proximal airway identifies subsets of known airway cell types revealing details of the unique molecular pathogenesis of Cystic Fibrosis

The paper uses single-cell transcriptomics to analyze proximal airway epithelium in CF and healthy donors, identifying molecular changes linked to CF pathogenesis.

Using virtual reality and thermal imagery to improve statistical modelling of vulnerable and protected species

The paper combines virtual reality and thermal imagery with statistical models to improve koala distribution predictions and conservation efforts.

KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors

This paper investigates how structural modifications in SFTI-based inhibitors affect their interaction with KLK4, revealing insights into protease inhibition dynamics.