A. Parker

Selective inhibitors of JAK1 targeting a subtype-restricted allosteric cysteine

This study identifies an allosteric cysteine in JAK1 and TYK2, develops inhibitors targeting it, and shows high subtype selectivity with minimal off-target effects.

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

Improved methods for protein and single-molecule RNA detection in C. elegans embryos

The paper improves IF and smFISH methods for C. elegans embryos to enable combined mRNA and protein analysis in the same sample.

Elevated nest temperature has opposing effects on host species infested with parasitic nest flies

The paper examines how elevated nest temperature affects parasite abundance in two host species, finding opposing effects on parasite infestation in eastern bluebirds and tree swallows.

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

This study analyzes nasopharyngeal samples from COVID-19 patients and healthy controls to identify how SARS-CoV-2 infection affects respiratory epithelial cells and immune responses, finding impaired local intrinsic immunity in severe cases.

Effects of germline and somatic events in candidate BRCAness genes on breast-tumor signatures

The paper examines how germline and somatic events in BRCAness-related genes affect breast-tumor signatures, finding similarities between BRCA1/BRCA2 aberrations and other genes like ATR and BARD1.

MDM2 Inhibition in Combination with Endocrine Therapy and CDK4/6 Inhibition for the Treatment of ER-Positive Breast Cancer.

This study evaluates MDM2 inhibition combined with endocrine therapy and CDK4/6 inhibition in ER-positive breast cancer, showing synergistic anti-tumor effects in resistant models.

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

Flux-Balance Based Modeling of Biofilm Communities

The paper proposes a kinetics-free methodology combining cellular metabolic flux analysis with macro-scale microbial community models to study biofilm communities.

The impact of experimental design choices on parameter inference for models of growing cell colonies

This study investigates how experimental design affects parameter inference in models of growing cell colonies, finding that initial spatial heterogeneity improves inference without cell tracking.

A hierarchical Bayesian framework for understanding the spatiotemporal dynamics of the intestinal epithelium

The paper develops a hierarchical Bayesian framework to model spatiotemporal dynamics of intestinal epithelium proliferation and migration under different conditions, concluding a proliferation-driven model is sufficient for most time-scales.