Author

A. Shams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

F. Jiang· 3 shared J. E. Bird· 3 shared G. M. Alushin· 2 shared J. R. Sellers· 2 shared M. R. Bowl· 2 shared R. Gong· 2 shared T. B. Friedman· 2 shared Y. Takagi· 2 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCell Biology

F. Jiang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Role of autophagy in sepsis-induced skeletal muscle dysfunction, whole-body metabolism, and survival

J.-P. Leduc-Gaudet, K. Miguez, M. Cefis, A. Moamer, T. J. Chaffer, J. Faitg, O. Reynaud, F. E. Broering, A. Shams, D. Mayaki, L. Huck, M. Sandri, G. Gouspillou, S. Hussain

This study shows that blocking autophagy in skeletal muscles during sepsis worsens muscle dysfunction and reduces survival, suggesting autophagy is protective.

bioRxiv · Aug 5, 2021Cell Biology

Myosin-driven Nucleation of Actin Filaments Drives Stereocilia Development Critical for Hearing

Z. G. Moreland, F. Jiang, C. Aguilar, M. Barzik, R. Gong, A. Shams, C. Faaborg-Andersen, J. C. Werth, R. Harley, D. C. Sutton, S. M. Cole, A. Parker, S. Morse, E. Wilson, Y. Takagi, , J. E. Bird

This study identifies a mutation in MYO15 that disrupts actin nucleation at stereocilia tips, causing hearing loss by impairing stereocilia growth.

bioRxiv · Jul 9, 2021 · PreprintCell Biology

Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia

R. Gong, F. Jiang, Z. G. Moreland, M. J. Reynolds, S. Espinosa de los Reyes, P. S. Gurel, A. Shams, M. R. Bowl, J. E. Bird, G. M. Alushin

This paper presents cryo-EM structures of myosin-15 bound to F-actin, revealing how mutations affect actin polymerization and stereocilia elongation.

bioRxiv · Jul 9, 2021Biophysics

The ATPase mechanism of myosin 15, the molecular motor mutated in DFNB3 deafness

F. Jiang, Y. Takagi, A. Shams, S. M. Heissler, T. B. Friedman, J. R. Sellers, J. E. Bird

This study characterizes the ATPase mechanism of MYO15A, a motor protein involved in stereocilia development, and identifies its kinetic properties relevant to hearing loss.

bioRxiv · Jun 17, 2020Biochemistry