Enhanced inflammatory signaling driven by metabolic switch in Aicardi-Goutieres syndrome
M. Batignes, M. Luka, S. Jagtap, C. de Cevins, I. Nemazanyy, T. Fali, V. Garcia-Paredes, F. Carbone, B. P. Perot, B. Neven, B. Bader-Meunier, P. Quartier dit Maire, M. Hully, A. Belot, A. Lepelley, , M. M. Menager
This study identifies a metabolic switch and loss of HIF-1 activity in AGS patients, showing that stabilizing HIF-1 reduces inflammation and IP-10 production.
bioRxiv · Feb 23, 2023 · PreprintImmunology