M. Luka

Single nuclei transcriptomics reveal the differentiation trajectories of periosteal skeletal/stem progenitor cells in bone regeneration

The paper uses single-nuclei transcriptomics to map periosteal skeletal stem/progenitor cell differentiation during bone regeneration, identifying injury-induced fibrogenic cells and their role in osteogenesis and chondrogenesis.

Enhanced inflammatory signaling driven by metabolic switch in Aicardi-Goutieres syndrome

This study identifies a metabolic switch and loss of HIF-1 activity in AGS patients, showing that stabilizing HIF-1 reduces inflammation and IP-10 production.

Novel repertoire of tau biosensors to monitor pathological tau transformation and seeding activity in living cells

This paper develops tau biosensors using Nanoluciferase technology to monitor tau conformational changes and seeding activity in living cells, identifying potential therapeutic targets for tauopathies.

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

The paper identifies a monocyte/dendritic cell gene signature in severe MIS-C with myocarditis, linked to NF-κB activity and cytokine signaling.

Maturation and persistence of the anti-SARS-CoV-2 memory B cell response.

This study tracks the maturation of SARS-CoV-2-specific memory B cells over 6 months, showing their persistence and mutation accumulation.

Direct contribution of skeletal muscle mesenchymal progenitors to bone repair

This study shows skeletal muscle mesenchymal progenitors contribute to bone repair by first forming fibrous tissue and then supporting cartilage and bone formation, but fail to do so in polytrauma leading to impaired healing.

A comprehensive map of the dendritic cell transcriptional network engaged upon innate sensing of HIV

This study maps the transcriptional network in HIV-1 infected dendritic cells, identifying key regulators of interferon response and maturation.