Author

A. Belot

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

B. Bader-Meunier· 3 shared F. Rieux-Laucat· 2 shared S. Georgin-Lavialle· 2 shared T. Henry· 2 shared Y. Jamilloux· 2 shared A. Bouafia· 1 shared A. Duquesne· 1 shared A. Fischer· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

B. Bader-Meunier

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Functional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.

C. Cosson, R. Riou, D. Patoli, T. Niu, A. Rey, M. Groslambert, E. Chatre, O. Allatif, T. Henry, F. Venet, F. Milhavet, G. Boursier, A. Belot, Y. Jamilloux, E. Merlin, , B. F. Py

This study functionally characterizes 34 NLRP3 variants associated with CAPS, identifying functional diversity and inhibitor sensitivity, with implications for diagnosis and drug development.

bioRxiv · Sep 22, 2023 · PreprintImmunology

Enhanced inflammatory signaling driven by metabolic switch in Aicardi-Goutieres syndrome

M. Batignes, M. Luka, S. Jagtap, C. de Cevins, I. Nemazanyy, T. Fali, V. Garcia-Paredes, F. Carbone, B. P. Perot, B. Neven, B. Bader-Meunier, P. Quartier dit Maire, M. Hully, A. Belot, A. Lepelley, , M. M. Menager

This study identifies a metabolic switch and loss of HIF-1 activity in AGS patients, showing that stabilizing HIF-1 reduces inflammation and IP-10 production.

bioRxiv · Feb 23, 2023 · PreprintImmunology

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

D. B. Hristova, M. Oliveira, E. Wagner, A. Melcher, K. J. Harrington, A. Belot, B. J. Ferguson

This study shows DNA-PK is essential for STING-dependent IFN-I responses to exogenous DNA and DNA virus infection in human cells.

bioRxiv · Nov 1, 2022Immunology

Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

F. Magnotti, D. Chirita, S. Dalmon, A. Martin, P. Bronnec, J. Sousa, o. Helynck, W. Lee, D. Kastner, J. J. Chae, M. McDermott, a. Belot, M. Popoff, P. Seve, S. Georgin-Lavialle, , T. Henry

This study identifies steroid hormone catabolites as specific activators of the pyrin inflammasome through a non-canonical mechanism, linking them to autoinflammation and explaining steroid fever.

bioRxiv · Oct 29, 2021Immunology

Heterozygous RELA mutations cause early-onset systemic lupus erythematosus by hijacking the NF-κB pathway towards transcriptional activation of type-I Interferon genes

L. Barnabei, H. Lamrini, M. Castela, N. Jeremiah, M.-C. Stolzenberg, L. Chentout, S. Mirshavalad, A. Bouafia, A. Magerus, M. Moncan, S. Jacques, O. Pelle, V. Bondet, D. Duffy, M. Parisot, , F. Rieux-Laucat

This study identifies heterozygous RELA mutations in early-onset SLE patients, showing they drive type-I interferon gene expression through NF-κB pathway hijacking.

bioRxiv · Apr 27, 2020 · PreprintImmunology