Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in Toxoplasma gondii.
A. Rozenberg, M. R. Luth, M. Behnke, E. Winzeler, L. D. Sibley
This study identifies novel mutations in Toxoplasma gondii that confer resistance to artemisinin, including mitochondrial genome amplification and changes in mitochondrial function.
Proceedings of the National Academy of Sciences · Dec 5, 2019Peer-reviewedMicrobiology