Author

M. R. Luth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

E. A. Winzeler· 2 shared S. Ottilie· 2 shared A. F. Cowman· 1 shared A. K. Lukens· 1 shared A. L. Cheung· 1 shared A. Rozenberg· 1 shared B. Y. Zou· 1 shared D. A. Fidock· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersMicrobiology

E. A. Winzeler

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Collateral sensitivity as a strategy to suppress resistance emergence: the challenge of diverse evolutionary pathways

R. E. K. Mandt, M. R. Luth, M. A. Tye, R. Mazitschek, S. Ottilie, E. A. Winzeler, M. J. Lafuente-Monasterio, F. J. Gamo, D. F. Wirth, A. K. Lukens

This study investigates collateral sensitivity between DHODH inhibitors to suppress malaria resistance, finding that cross-resistant mutants can emerge despite initial sensitivity.

bioRxiv · Apr 7, 2022Microbiology

Evolution of resistance in vitro reveals a novel mechanism of artemisinin activity in Toxoplasma gondii.

A. Rozenberg, M. R. Luth, M. Behnke, E. Winzeler, L. D. Sibley

This study identifies novel mutations in Toxoplasma gondii that confer resistance to artemisinin, including mitochondrial genome amplification and changes in mitochondrial function.

Proceedings of the National Academy of Sciences · Dec 5, 2019Peer-reviewedMicrobiology

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

G. M. LaMonte, D. S. Marapana, N. Gnadig, S. Ottilie, M. R. Luth, T. S. Worgall, F. Rocamora, G. M. Goldgof, R. Mohunlal, T. R. S. Kumar, J. K. Thompson, E. Vigil, J. Yang, D. Hutson, T. Johnson, , E. A. Winzeler

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

bioRxiv · Aug 15, 2019Microbiology