Receptor-interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy
M. Bencze, B. Periou, I. Punzon, I. Barthelemy, V. Taglietti, C. Hou, L. Zaidan, K. Kefi, S. Blot, O. Agbulut, M. Gervais, G. Derumeaux, L. Tiret, F. J. Authier, F. Relaix
This study shows that inhibiting necroptosis in dystrophic mice improves cardiac and skeletal muscle function, suggesting necroptosis contributes to DMD-related myopathy and cardiomyopathy.
bioRxiv · Jan 6, 2022Cell Biology