C. Hou

NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis

This study identifies NSD2 as a critical component of the AR neo-enhanceosome in prostate cancer, showing its role in AR enhancer circuitry and tumor progression.

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

Nephrectomy and high-salt diet inducing pulmonary hypertension and kidney damage by increasing Ang II concentration in rats

This study develops a CKD-PH rat model through 5/6 nephrectomy and high-salt diet, showing increased Ang II and RAAS imbalance, ACE2 downregulation, and metabolic changes linked to pulmonary hypertension.

Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells

This study shows that abemaciclib resistance in breast cancer cells is linked to increased metastatic potential and lysosomal protein deregulation, with potential therapeutic implications for combining lysosomal destabilizers.

Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

Peptidoglycan recognition protein S2 is crucial for activation the Toll pathway against Israeli acute paralysis virus infection in honey bee Apis mellifera

This study identifies the Toll pathway as a key antiviral defense in honey bees, with PGRP-S2 acting as a pattern recognition receptor that interacts with viral proteins to activate the pathway against IAPV infection.

Fate tracing reveals differences between Reelin+ HSCs and Desmin+ HSCs in activation, migration, and proliferation activities

This study compares Reelin+ HSCs and Desmin+ HSCs in liver fibrosis using fate tracing, showing differences in activation, migration, and proliferation in response to cholestatic and hepatotoxic injuries.

Receptor-interacting protein kinase-3 mediates both myopathy and cardiomyopathy in preclinical animal models of Duchenne muscular dystrophy

This study shows that inhibiting necroptosis in dystrophic mice improves cardiac and skeletal muscle function, suggesting necroptosis contributes to DMD-related myopathy and cardiomyopathy.

Interferon-gamma mediates skeletal muscle lesions through JAK/STAT pathway activation in inclusion body myositis

This study shows that IFN-gamma induces skeletal muscle degeneration via JAK/STAT pathway activation in IBM, with ruxolitinib reversing these effects.

A chloride efflux transporter OsBIRG1 regulates grain size and salt tolerance in rice

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

Ubiquitination and degradation of NF90 by Tim-3 inhibits antiviral innate immunity

This study shows Tim-3 promotes NF90 ubiquitination and degradation, inhibiting antiviral innate immunity via stress granule formation.

Quantifying phase separation property of chromatin associated proteins under physiological conditions using anti-1,6-hexanediol index

The paper quantifies the phase separation properties of chromatin-associated proteins using an anti-1,6-hexanediol index and shows functional correlations with chromatin organization.

Universal rules of life: metabolic rates, biological times and the equal fitness paradigm

The paper reviews and extends the equal fitness paradigm to link metabolism, energy allocation, and universal rules of life across ecological and evolutionary scales.

Oxidative stress pathogenically remodels the cardiac myocyte cytoskeleton via structural alterations to the microtubule lattice

This study shows oxidative stress causes structural changes in cardiac myocyte microtubules, leading to a static, acetylated network that contributes to heart failure.

A metabolic life table exemplified by sockeye salmon

This paper develops a metabolic life table for sockeye salmon to quantify energy budget and life history across their life cycle, revealing key metabolic patterns and ecosystem impacts.

Design to Data for mutants of β-glucosidase B from Paenibacillus polymyxa: Q22T, W123R, F155G, Y169M, W438D, V401A

The paper quantifies thermal stability and catalytic efficiency of six β-glucosidase B mutants and adds the data to a dataset to improve Rosetta algorithms for protein engineering.

An electrostatic-interaction-based mechanism triggering misfolding of prion proteins from cellular isoform to scrapie isoform

This paper proposes an electrostatic-interaction-based mechanism for prion protein refolding from PrPC to PrPSc, identifying key steps involving hydrophobic interactions and pH changes.

Three-dimensional Genome Structure Reveals Distinct Chromatin Signatures of Mouse Female Germline Stem Cells During Development

The paper examines the 3D chromatin structure of mouse female germline stem cells during development, identifying changes in TADs and conserved compartments related to imprinted genes.

Monitoring the depth of anesthesia using Autoregressive model and Sample entropy

This paper develops a method to monitor anesthesia depth using EEG features from sample entropy and autoregressive models, achieving high correlation with BIS index.