Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy
J. Shaw, R. Gosein, M. M. Kalita, J. Kankanala, D. R. Mahato, T. Foster, C. Scott, E. Brown, B. J. King, M. Bentham, L. Wetherill, A. Bloy, A. Samson, M. Harris, J. Mankouri, , S. Griffin
The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.
bioRxiv · Oct 7, 2019Microbiology