C. Scott

Imaging the structural connectome with hybrid diffusion MRI-microscopy tractography

This paper develops a hybrid diffusion MRI-microscopy tractography method to improve 3D brain connectivity reconstruction by combining high-resolution microscopy with diffusion MRI data.

Asymmetric ene-reduction of α,β-unsaturated compounds by F420-dependent oxidoreductases A (FDOR-A) enzymes from Mycobacterium smegmatis

This study characterizes FDOR-A enzymes from Mycobacterium smegmatis, showing their ability to asymmetrically reduce α,β-unsaturated compounds with high enantioselectivity.

Deep topographic proteomics of a human brain tumour

This paper develops a workflow for spatially-resolved proteomics in human brain tumours, identifying spatial markers and immune-related protein networks in tissue slices.

In an "ecological-belonging" intervention to reduce inequities in STEM, context matters

This study examines the effectiveness of an ecological-belonging intervention in reducing performance gaps in STEM courses, finding it more effective in threatening classroom contexts.

Ovarian carcinosarcoma genomics and pre-clinical models highlight the N-MYC pathway as a key driver and susceptibility to EMT-targeting therapy

This study identifies N-MYC pathway activation and susceptibility to EMT-targeting therapy in ovarian carcinosarcoma using genomic and pre-clinical models.

Temporal emergence of age-associated changes in cognitive and physical function in vervets (Chlorocebus aethiops sabaeus)

This study examines age-related declines in cognitive and physical function in vervet monkeys, finding coordinated declines and a link between slow gait and cognitive performance.

Genetic ablation of serotonin receptor 2B improves aortic valve hemodynamics in a high-cholesterol diet mouse model

This study shows genetic ablation of Htr2b reduces hemodynamic indicators of aortic valve stenosis in a mouse model of CAVD, but pharmacological antagonism had no effect.

Open Source ImmGen: network perspective on metabolic diversity among mononuclear phagocytes

The paper analyzes metabolic diversity in mononuclear phagocytes across tissues using integrated datasets and a network-based approach, identifying key metabolic subnetworks and their functional roles.

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

Site-directed M2 proton channel inhibitors enable synergistic combination therapy for rimantadine-resistant pandemic influenza

The paper identifies M2-N31 inhibitors that show synergistic antiviral effects when combined with existing drugs, offering a strategy to combat rimantadine-resistant influenza.