Author

J. Mankouri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

A. Macdonald· 2 shared A. Samson· 2 shared A. Whitehouse· 2 shared C. W. Wasson· 2 shared J. Fontana· 2 shared A. B. Shaw· 1 shared A. Bloy· 1 shared A. Moon-Walker· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

A. Macdonald

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Organisation of the orthobunyavirus tripodal spike and the structural changes induced by low pH and K+ during entry

S. Hover, F. Charlton, J. Hellert, J. Barr, J. Mankouri, J. Fontana

The paper uses cryo-EM and AlphaFold to model the BUNV spike and shows how low pH and high K+ induce structural changes in the glycoproteins to facilitate entry.

Nature Communications · Sep 21, 2023Peer-reviewedMicrobiology

Cellular endosomal potassium ion flux regulates arenavirus uncoating during virus entry

A. B. Shaw, H. N. Tse, O. Byford, g. plahe, A. Moon-Walker, E. O. Saphire, S. P. J. Whelan, J. Mankouri, J. Fontana, J. N. Barr

This study identifies potassium ion flux as a third requirement for LCMV entry, showing it facilitates uncoating by modulating NP/Z interactions.

bioRxiv · Jun 23, 2023Cell Biology

Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling

J. A. Scarth, C. W. Wasson, M. R. Patterson, D. Evans, D. Barba-Moreno, H. Carden, A. Whitehouse, J. Mankouri, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV exploits KATP channels to promote cervical cancer cell proliferation through MAPK/AP-1 signaling.

bioRxiv · Sep 22, 2022Microbiology

Chloride intracellular channel 4 (CLIC4) expression is transcriptionally regulated by crosstalk of the TGF-beta, Wnt and Hedgehog signalling pathways

C. W. Wasson, B. Caballero-Ruiz, J. Mankouri, G. Canettieri, N. A. Riobo-Del Galdo, F. Del Galdo

This study identifies that TGF-beta, Wnt, and Hedgehog signaling pathways cooperatively regulate CLIC4 expression in fibroblasts, with implications for fibrosis.

bioRxiv · Jun 29, 2021 · PreprintCell Biology

A requirement for Potassium and Calcium Channels during the Endosomal Trafficking of Polyomavirus Virions

S. J. Dobson, J. Mankouri, A. Whitehouse

This study identifies the role of K+ and Ca2+ channels in polyomavirus infection, showing that Ca2+ channels are essential for both SV40 and MCPyV, while MCPyV is also sensitive to K+ channel blockage.

bioRxiv · Oct 22, 2019 · PreprintMicrobiology

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

J. Shaw, R. Gosein, M. M. Kalita, J. Kankanala, D. R. Mahato, T. Foster, C. Scott, E. Brown, B. J. King, M. Bentham, L. Wetherill, A. Bloy, A. Samson, M. Harris, J. Mankouri, , S. Griffin

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

bioRxiv · Oct 7, 2019Microbiology