E. Brown

Human placental organoids as a model to probe early gestation maternal immune dynamics

This study uses human placental organoids to investigate trophoblast subtypes' roles in modulating maternal immune responses and shows 3D culture affects immunomodulation differently than 2D culture.

Student experiences with an interactive 3D immersive biotechnology simulation and its impact on motivational beliefs

This study evaluates a 3D immersive biotechnology simulation's impact on students' science motivational beliefs, finding increased self-efficacy and positive perceptions.

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior

This paper introduces a micro-fiber array system for measuring and manipulating neural dynamics in large brain volumes during behavior, revealing spatiotemporal patterns of dopamine release and enabling precise optogenetic control.

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

Physics-informed deep generative learning for quantitative assessment of the retina

This paper introduces a physics-informed GAN to generate realistic retinal blood vessel models, outperforming human labeling in segmentation and reconstruction.

Microengineering 3D Collagen Matrices with Tumor-Mimetic Gradients in Fiber Alignment

This study creates 3D collagen matrices with tumor-mimetic fiber alignment gradients to investigate their effect on cell migration.

TORC1 is an essential regulator of nutrient-dependent differentiation in Leishmania

This study identifies TORC1 as essential for nutrient-dependent differentiation in Leishmania, showing its role in both promastigote and amastigote stages.

Inferring transmission routes for foot-and-mouth disease virus within a cattle herd using approximate Bayesian computation

This study uses approximate Bayesian computation to infer transmission routes of FMDV within a cattle herd, finding direct contact contributes most infections but environmental contamination also plays a role.

Novelty detection and multiple timescale integration drive Drosophila orientation dynamics in temporally diverse olfactory environments

This study investigates how Drosophila navigates odor plumes by analyzing the impact of odor timing on orientation dynamics and finds that flies use a combination of frequency-dependent responses and two-timescale filtering.

Cysteine post-translational modifications regulate protein interactions of caveolin-3

This study identifies cysteine post-translational modifications in caveolin-3 that regulate its protein interactions and structural properties in muscle cells.

High Resolution Imaging of the Osteogenic and Angiogenic Interface at the Site of Cranial Bone Defect Repair via Multiphoton Microscopy

This study uses multiphoton microscopy to examine blood vessel dynamics and oxygen metabolism during cranial bone defect repair, revealing differential metabolic responses between endothelial cells and osteoblasts.

Global change drivers and the risk of infectious disease

This study identifies global change drivers most associated with increases in infectious diseases across human and non-human systems.

Remodeling of human colon plasma cell repertoire in ulcerative colitis

This study characterizes the remodeling of the human colon plasma cell repertoire in ulcerative colitis, showing clonal expansion, isotype skewing, and altered gene expression associated with inflammation.

MEK inhibition enhances presentation of targetable MHC-I tumor antigens in mutant melanomas

This study shows MEK inhibition increases MHC-I antigen presentation in melanoma, enhancing immunotherapy efficacy through targeted epitopes.

Genomic Evidence of Environmental and Resident Salmonella Senftenberg and Montevideo Contamination in the Pistachio Supply-chain

This study analyzes Salmonella contamination in pistachios using genomic data to identify persistent strains and their adaptation mechanisms.

Inhibitors of the Small Membrane (M) Protein Viroporin Prevent Zika Virus Infection

This study identifies the ZIKV M protein as a therapeutic target, showing that inhibitors like rimantadine block viral infection in vitro and in vivo by targeting M-formed channels.

Toll-9 interacts with Toll-1 to mediate a feedback loop during apoptosis-induced proliferation in Drosophila

The paper shows Toll-9 interacts with Toll-1 to drive apoptosis-induced proliferation through NF-κB-like signaling in Drosophila.

Essential roles for deubiquitination in Leishmania life cycle progression

This study identifies essential deubiquitinating enzymes (DUBs) in Leishmania life cycle progression and demonstrates their critical role in differentiation and intracellular survival.

Rationally derived inhibitors of hepatitis C virus (HCV) p7 channel activity reveal prospect for bimodal antiviral therapy

The paper designs a rationally derived inhibitor of HCV p7 channel activity, revealing its dual role in virus entry and infection spread, and highlights its potential for bimodal antiviral therapy.

The Y chromosome contributes to sex-specific aging in Drosophila

This study shows that Y chromosome repeats become de-repressed faster in aging male Drosophila, contributing to shorter lifespan compared to females.

Exposure to parasitic protists and helminths changes the intestinal community structure of bacterial microbiota but not of eukaryotes in a cohort of mother-child binomial from a semi-rural setting in Mexico

This study examines how exposure to intestinal parasites affects bacterial and eukaryotic microbiota in a mother-child cohort in Mexico, finding significant bacterial community changes but not eukaryotic ones.

Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors

This study identifies CLK1 as a novel drug target in Trypanosoma brucei by showing its essential role in kinetochore function and cell survival through kinase inhibition.

Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria

This paper determines the structure of TagA, a glycosyltransferase involved in wall teichoic acid biosynthesis, and reveals its mechanism of catalysis and regulation by membrane interactions.

Geographic variation in sleep and metabolic function is associated with latitude and temperature

The paper examines sleep and metabolic traits in Drosophila populations across geographic regions, finding associations with latitude, temperature, and metabolic indicators.