Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties
T.-E. Park, N. Mustafaoglu, A. Herland, R. M. Hasselkus, R. Mannix, E. A. FitzGerald, R. Prantil-Baun, A. Watters, O. Henry, M. Benz, H. Sanchez, H. J. McCrea, L. Christova Goumnerova, H. W. Song, S. P. Palecek, , D. E. Ingber
This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.
bioRxiv · Nov 29, 2018 · PreprintBioengineering