H. Sanchez

Cell Cycle Regulation has Shaped Budding Yeast Replication Origin Structure and Function

The paper shows that CDK regulation influences MCM helicase loading at yeast origins, revealing how cell cycle control has shaped origin structure and function.

Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the ZCF15 and ZCF26 paralogs

This study identifies ZCF15 and ZCF26 as biofilm regulators in Candida albicans that modulate metabolic reprogramming during the planktonic-to-biofilm transition.

A chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint

The paper investigates ORC and MCM dynamics at chromatinized origins in yeast, finding that chromatin reduces MCM mobility while maintaining ORC binding efficiency.

Assessment of the Glycan-Binding Profile of Pseudomonas aeruginosa PAO1

This study identifies the glycan-binding preferences of Pseudomonas aeruginosa PAO1 using glycan arrays and exogenous glycans, showing a preference for monosaccharides over complex structures.

Nucleotide binding halts diffusion of the eukaryotic replicative helicase during activation

This study reports the first single-molecule activation of CMG reconstituted from purified yeast proteins and quantifies its DNA motion, showing nucleotide binding halts diffusion and enables DNA melting.

A robotic platform for fluidically-linked human body-on-chips experimentation

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.