Author

R. Mannix

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 4

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:organoid / primary culture· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

A. Herland· 2 shared D. E. Ingber· 2 shared E. A. Fitzgerald· 2 shared H. Sanchez· 2 shared O. Henry· 2 shared T.-E. Park· 2 shared A. Chalkiadaki· 1 shared A. Cho· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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2 shared papersBioengineering

A. Herland

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Hemoxygenase-1 as a key mediator of acute radiation pneumonitis revealed in a human lung alveolus-on-a-chip

Q. Dasgupta, A. Jiang, S. Hall, R. Mannix, A. M. Wen, D. E. Ingber

This study uses a human lung alveolus-on-a-chip to show that HMOX-1 mediates acute radiation-induced lung injury and that its activation reduces early injury but worsens later damage.

bioRxiv · Feb 13, 2023Bioengineering

BBB pathophysiology independent delivery of siRNA in traumatic brain injury

W. Li, J. Qiu, X.-L. Li, S. Aday, J. Zhang, G. Conley, J. Xu, R. Langer, R. Mannix, J. M. Karp, N. Joshi

This paper develops a nanoparticle platform for BBB-independent siRNA delivery in TBI, achieving higher brain accumulation and gene silencing through surface chemistry and coating density modulation.

bioRxiv · Jun 26, 2020Bioengineering

A robotic platform for fluidically-linked human body-on-chips experimentation

R. Novak, M. Ingram, S. Clauson, D. Das, A. Delahanty, A. Herland, B. Maoz, S. S. F. Jeanty, M. R. Somayaji, M. Burt, E. Calamari, A. Chalkiadaki, A. Cho, Y. Choe, D. B. Chou, , B. Swenor

The paper introduces an automated platform for culturing and analyzing human Organ Chips, demonstrating its ability to maintain organ function and predict tracer distribution using a computational model.

bioRxiv · Mar 6, 2019 · PreprintBioengineering

Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties

T.-E. Park, N. Mustafaoglu, A. Herland, R. M. Hasselkus, R. Mannix, E. A. FitzGerald, R. Prantil-Baun, A. Watters, O. Henry, M. Benz, H. Sanchez, H. J. McCrea, L. Christova Goumnerova, H. W. Song, S. P. Palecek, , D. E. Ingber

This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.

bioRxiv · Nov 29, 2018 · PreprintBioengineering