R. Prantil-Baun

This paper develops a human vagina-on-a-chip model to study vaginal microbiome-host interactions and their effects on health outcomes.

This paper establishes a method to create physiologically relevant oxygen gradients in a microfluidic intestine-on-a-chip model, supporting stable oxygen levels and intestinal barrier integrity.

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

This paper uses an intestine-on-a-chip model to study NL63 coronavirus infection effects on the human intestine and tests antiviral treatments.

This paper develops a simulation and experimental method to predict drug concentration profiles in PDMS microfluidic organ chips without prior knowledge of log P or diffusion rates.

This paper demonstrates the formation of lymphoid follicles in a human organ-on-a-chip model and shows improved vaccine responses compared to 2D cultures.

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

This study develops a human colon-on-a-chip model that replicates the mucus bilayer structure and function, enabling real-time non-invasive analysis of mucus layer dynamics.

The paper uses a human airway chip to discover influenza drug resistance mutations and identify host therapeutic targets for antiviral drugs.

The paper identifies human gut microbiome metabolites that enhance EHEC pathogenesis in a human colonic organ chip model, contributing to species-specific susceptibility.