Aggressive KRAS mutations direct TGF-β response towards partial EMT in patient-derived colorectal cancer tumoroids
T. Mair, P. König, M. Mijovic, L. Tran, P. M. Saldana, C. U. P. Malla, K. Draganic, J. Pfneissl, A. Tiefenbacher, J. Kabiljo, V. S. Atanasova, J. Kalla, L. Wozelka-Oltjan, L. Müllauer, M. Bergmann, , G. Egger
This study investigates how TGF-β affects colorectal cancer tumoroids, finding that aggressive KRAS mutations lead to partial EMT and increased invasiveness.
bioRxiv · Jun 25, 2024 · PreprintCancer Biology