Author

C. Binder

Heidelberg University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Bioengineering· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Alimohammadi· 1 shared A. Bleckmann· 1 shared A. Farhat· 1 shared A. Hladik· 1 shared A. Janshoff· 1 shared A. Korosec· 1 shared A. Tiefenbacher· 1 shared A. U. Eriksson· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperImmunology

A. Alimohammadi

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

Helen F. Dietmar, Nicole Hecht, C. Binder, S. Schmidt, T. Walker, S. Grässel, W. Richter, S. Diederichs

This study shows that CGRP impairs load-stimulated proteoglycan production in human chondrocytes by modulating WNT activity, suggesting a new therapeutic target for osteoarthritis.

bioRxiv · Oct 11, 2024 · PreprintCell Biology

A neutrophil-B-cell axis governs disease tolerance during sepsis via Cxcr4

R. Gawish, B. Maier, G. Obermayer, M. Watzenboeck, A.-D. Gorki, F. Quattrone, A. Farhat, K. Lakovits, A. Hladik, A. Korosec, A. Alimohammadi, I. Mesteri, F. Oberndorfer, F. Oakley, J. Brain, , S. Knapp

This study identifies a neutrophil-B-cell axis that promotes disease tolerance during sepsis through Cxcr4 activation, reducing organ damage and immunothrombosis.

bioRxiv · Mar 21, 2022Immunology

High throughput screen in a co-culture model to uncover therapeutic strategies to potentiate the cancer-inhibiting properties of the tumor-stroma in pancreatic cancer

J. E. Mason, J. Cumming, A. U. Eriksson, C. Binder, M. Dongre, C. Patthey, M. Espona-Fiedler, E. Chorell, D. Ohlund

The paper identifies GNF-5 as a compound that inhibits PDAC tumor cell growth by inducing myCAF phenotype in a co-culture model.

bioRxiv · Mar 11, 2022 · PreprintCancer Biology

Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model

V. S. Atanasova, C. d. J. Cardona, V. Hejret, A. Tiefenbacher, L. Tran, C. Binder, T. Mair, J. Kabiljo, J. Clement, K. Woeran, B. Neudert, M. Hengstschlaeger, M. Mitterhauser, L. Muellauer, B. Tichy, , G. Egger

This paper develops a colorectal cancer organoid model incorporating patient-derived fibroblasts, showing enhanced cellular heterogeneity and morphology compared to mono-cultures.

bioRxiv · Mar 7, 2022Cancer Biology

WNT11 is a novel ligand for ROR2 in human breast cancer

K. Menck, S. Heinrichs, D. Wlochowitz, M. Sitte, H. Noeding, A. Janshoff, H. Treiber, T. Ruhwedel, B. Schatlo, C. von der Brelie, S. Wiemann, T. Pukrop, T. Beissbarth, C. Binder, A. Bleckmann

The paper identifies WNT11 as a novel ligand for ROR2 in breast cancer, showing it promotes invasion through RHO/ROCK signaling and forms an auto-stimulatory loop.

Journal of Experimental & Clinical Cancer Research · Dec 15, 2021Peer-reviewedCancer Biology

WAT’s up!? – Organ-on-a-chip integrating human mature white adipose tissues for mechanistic research and pharmaceutical applications

J. Rogal, C. Binder, E. Kromidas, C. Probst, S. Schneider, K. Schenke-Layland, P. Loskill

The paper develops a WAT-on-a-chip system to study human white adipose tissue function and drug responses in obesity and diabetes.

bioRxiv · Mar 21, 2019Bioengineering