C. Wagner

FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses

The paper shows FoxO factors in Drosophila, mouse, and human airway epithelial cells respond to stressors by nuclear translocation, with FoxO-dependent stress pathways altered in asthma across species.

Small molecule STAT3/5 inhibitors exhibit therapeutic potential in acute myeloid leukemia and extra-nodal natural killer/T cell lymphoma

This study evaluates small molecule STAT3/5 inhibitors for treating AML and NKCL, showing growth arrest and synergy with existing therapies in vitro and in vivo.

Development of a PNGase Rc column for online deglycosylation of complex glycoproteins during HDX-MS

The paper develops a PNGase Rc column for online deglycosylation during HDX-MS, enabling efficient analysis of glycoproteins and mapping of mAb binding epitopes.

STAT5 Gain-of-Function Variants Promote Precursor T-Cell Receptor Activation to Drive T-Cell Acute Lymphoblastic Leukemia

This study identifies STAT5 gain-of-function mutations as drivers of T-ALL by promoting pre-TCR signaling and shows therapeutic targeting potential with STAT3/5 or ZAP70 inhibitors.

Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation

This study uses single-cell RNA sequencing to compare indolent primary cutaneous B-cell lymphomas with other B-cell proliferations, finding they resemble persistent antigen reactions with germinal center features.

Red blood cell lingering modulates hematocrit distribution in the microcirculation

This study quantifies how red blood cell lingering at microvascular bifurcations affects hematocrit distribution and shows its correlation with RBC membrane rigidity and bifurcation geometry.

ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity

This study shows that adipose tissue lipolysis via ATGL regulates hepatocyte PPARα activity, which is essential for ketone body production, FGF21 secretion, and BAT activation during fasting and cold exposure.

Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches

This study creates a spatial proteogenomic atlas of the liver across species, identifying conserved macrophage niches and their regulatory mechanisms.

Imaging erythrocyte sedimentation in whole blood

The paper uses optical imaging techniques to study erythrocyte sedimentation structures, finding dynamic channeling gel formations with varying detail resolution across methods.

Bexarotene derivatives modify responses in acute myeloid leukemia

This study screens bexarotene derivatives to identify compounds with enhanced anti-leukemic activity in AML, finding that dual RARA/RXRA activity and structural modifications affect potency and metabolic stability.

Limited within-host diversity and tight transmission bottlenecks limit SARS-CoV-2 evolution in acutely infected individuals

The paper analyzes SARS-CoV-2 within-host diversity and transmission bottlenecks in acute infections, finding limited diversity and narrow bottlenecks that restrict variant spread.

Single-cell sequencing of plasma cells from COVID-19 patients reveals highly expanded clonal lineages produce specific and neutralizing antibodies to SARS-CoV-2

Single-cell sequencing and screening identify expanded plasma cell clones in COVID-19 patients producing SARS-CoV-2-specific neutralizing antibodies.

Wild-captive contrasts in non-vocal communicative repertoires and functional specificity in orang-utans

This study compares communicative repertoires of wild and captive orang-utans, finding larger repertoires in captivity with increased functional specificity in sociable species.

Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

This study reconstructs the developmental pathways of HIV-specific ADCC antibodies and identifies mutations required for antigen binding and ADCC function.

A unified model of species abundance, genetic diversity, and functional diversity revealsthe mechanisms structuring ecological communities

The paper introduces a mechanistic model integrating species abundance, genetic diversity, and functional diversity to infer ecological community assembly processes using tropical tree, arthropod, and gastropod communities.

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma