A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel
A. Sridhar, S. C. R. Lummis, D. Pasini, A. Mehregan, M. Brams, K. Kambara, D. Bertrand, E. Lindahl, R. J. Howard, C. Ulens
This study identifies a cationic lipid binding site on the outward face of the ELIC pLGIC, supported by simulations and mutagenesis, with implications for lipid modulation and drug design.
bioRxiv · Mar 24, 2021 · PreprintBiophysics