Author

A. Sridhar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Microbiology· 2 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein folding & dynamics· 3 Approach:statistical model· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:structural biology· 2

Frequent Co-Authors

G. Krainer· 2 shared J. A. Joseph· 2 shared J. R. Espinosa· 2 shared K. C. Wolthers· 2 shared N. Johannesson· 2 shared R. Collepardo-Guevara· 2 shared S. Alberti· 2 shared T. J. Welsh· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersBiophysics

G. Krainer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Ecological interactions between host, commensal and pathogenic bacteria in models for the intestinal epithelium.

N. M. Nanlohy, N. Johannesson, L. Wijnands, L. Arroyo, J. de Wit, G. den Hartog, K. C. Wolthers, A. Sridhar, S. Fuentes

This study investigates epithelial responses to commensal and pathogenic bacteria using intestinal models, showing differences in immune activation between cell lines and organoids.

bioRxiv · Nov 9, 2023 · PreprintMicrobiology

Assessment of The Broad-Spectrum Host Targeting Antiviral Efficacy of Halofuginone Hydrobromide in Human Airway, Intestinal and Brain Organoid Models.

I. Garcia-Rodriguez, G. Moreni, P. E. Capendale, I. Aknouch, L. A. Mulder, N. Johannesson, R. Vieira de Sa, E. Freeze, H. van Eijk, G. Koen, K. C. Wolthers, D. Pajkrt, A. Sridhar, C. Calitz

This study evaluates the antiviral efficacy of halofuginone hydrobromide against multiple viruses in human organoid models, finding it effective only against SARS-CoV-2.

bioRxiv · Nov 1, 2023 · PreprintMicrobiology

Defining the Parameters to Improve Plant Regeneration with Developmental Regulators

R. A. Nasti, J. P. Cody, M. H. Zinselmeier, N. B. Badey, A. Sridhar, A. Sharma, M. F. Maher, B. K. A. Blackman, D. Voytas

This study identifies key parameters to optimize plant regeneration using developmental regulators in monocot and eudicot species.

bioRxiv · Nov 15, 2022 · PreprintPlant Biology

Markov State Modelling Reveals Heterogeneous Drug-Inhibition Mechanism of Calmodulin

A. M. Westerlund, A. Sridhar, L. Dahl, A. Andersson, A.-Y. Bodnar, L. Delemotte

This paper uses Markov state modeling and molecular dynamics simulations to analyze how the drug TFP inhibits CaM by stabilizing different conformations, revealing three distinct binding modes and their effects on CaM structure.

bioRxiv · Jun 8, 2022Biophysics

A cationic lipid site at the outward transmembrane face of a pentameric ligand-gated ion channel

A. Sridhar, S. C. R. Lummis, D. Pasini, A. Mehregan, M. Brams, K. Kambara, D. Bertrand, E. Lindahl, R. J. Howard, C. Ulens

This study identifies a cationic lipid binding site on the outward face of the ELIC pLGIC, supported by simulations and mutagenesis, with implications for lipid modulation and drug design.

bioRxiv · Mar 24, 2021 · PreprintBiophysics

Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

G. Krainer, T. J. Welsh, J. A. Joseph, J. R. Espinosa, S. Wittmann, E. de Csillery, A. Sridhar, Z. Toprakcioglu, G. Gudiskyte, M. A. Czekalska, W. E. Arter, P. St George-Hyslop, A. A. Hyman, R. Collepardo-Guevara, S. Alberti, T. P. Knowles

The paper shows that proteins forming liquid condensates can reenter a phase-separated state at high salt concentrations due to hydrophobic and non-ionic interactions, distinct from low-salt electrostatic-driven phase separation.

Nature Communications · Feb 17, 2021Peer-reviewedBiophysics

Surface electrostatics govern the emulsion stability of biomolecular condensates

T. J. Welsh, G. Krainer, J. R. Espinosa, J. A. Joseph, A. Sridhar, M. Jahnel, W. E. Arter, K. L. Saar, S. Alberti, R. Collepardo-Guevara, T. P. J. Knowles

The paper investigates how surface electrostatics influence the stability of biomolecular condensates by comparing their fusion propensity using zeta potential measurements and molecular modeling.

bioRxiv · Apr 20, 2020Biophysics