Structural mechanism of HP1-dependent transcriptional repression and chromatin compaction
V. Sokolova, J. Miratsky, V. Svetlov, M. Brenowitz, J. Vant, T. S. Lewis, K. Dryden, G. L. Lee, S. L. Sarkar, E. Nudler, A. Singharoy, D. Tan
This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.
bioRxiv · Nov 30, 2023Biochemistry