D. Tan

Structural mechanism of HP1-dependent transcriptional repression and chromatin compaction

This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.

Comparing virtual staining artificial intelligence model performance on same-tissue versus serial-tissue sections based on CD3+ T-cell ground truth

This study compares a virtual staining AI model's performance on same-tissue versus serial-tissue sections using CD3+ T-cell ground truth, finding better performance with same-tissue data.

A transcriptome-wide meta-analysis reveals lack of cancer-cell intrinsic determinants of response to immune checkpoint blockade

This study performs a transcriptome-wide meta-analysis to identify determinants of immune checkpoint blockade response, finding that stromal factors, not cancer-cell intrinsic features, are key predictors across tumor types.

Host-cell Interactions of Engineered T cell Micropharmacies

This study demonstrates that SEAKER cells, engineered T cells with prodrug-activating functions, effectively target solid tumors in immunocompetent hosts despite immune responses.

Design of a systemic small molecule clinical STING agonist using physics-based simulations and artificial intelligence

This paper designs a small molecule STING agonist, SNX281, using computational methods and AI, showing systemic activity and antitumor effects in mice.

Isolation and characterization of novel phages targeting pathogenic Klebsiella pneumoniae

This study isolates and characterizes three phages targeting MDR Klebsiella pneumoniae isolates, showing their lytic potential but also the emergence of phage-resistant mutants.

A robust field-based method to screen heat tolerance in wheat

This study introduces a photoperiod-extension method to screen wheat heat tolerance by synchronizing developmental phases, showing improved genotype ranking compared to conventional field trials.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.

Proliferation Saturation Index in an adaptive Bayesian approach to predict patient-specific radiotherapy responses

This paper develops a Bayesian model using proliferation saturation index to predict individual patient radiotherapy responses from clinical data.

Cryo-EM structure of an early precursor of large ribosomal subunit reveals a half assembled intermediate

The paper reports the cryo-EM structure of an early pre-60S ribosome intermediate, revealing a half-assembled subunit and key assembly factors involved in rRNA domain joining.