Author

E. Nudler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:chromatin & epigenetic regulation· 4 Assay:ChIP-seq· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

V. Svetlov· 3 shared C. Lu· 2 shared J. C. Zinder· 2 shared K. Gretarsson· 2 shared K.-J. Armache· 2 shared P. De Ioannes· 2 shared R. Lee· 2 shared S. Abini-Agbomson· 2 shared

Activity by Year

2021-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

V. Svetlov

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural mechanism of HP1-dependent transcriptional repression and chromatin compaction

V. Sokolova, J. Miratsky, V. Svetlov, M. Brenowitz, J. Vant, T. S. Lewis, K. Dryden, G. L. Lee, S. L. Sarkar, E. Nudler, A. Singharoy, D. Tan

This study determines the cryo-EM structure of HP1 bound to an H2A.Z nucleosome, revealing two binding sites and their roles in transcriptional repression and chromatin compaction.

bioRxiv · Nov 30, 2023Biochemistry

Rho and a riboswitch regulate mntP expression evading manganese stress and membrane toxicity

A. Prakash, A. Kalita, K. Bhardwaj, R. K. Mishra, D. Ghose, G. Kaur, B. Pani, E. Nudler, D. Dutta

The paper shows Rho terminates transcription at the mntP riboswitch, and manganese activates the riboswitch to restore transcription-translation coupling, preventing membrane toxicity from overexpressed MntP.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

S. Abini-Agbomson, K. Gretarsson, R. M. Shih, L. Hsieh, T. Lou, P. De Ioannes, N. Vasilyev, R. Lee, M. Wang, M. Simon, J.-P. Armache, E. Nudler, G. Narlikar, S. Liu, C. Lu, K.-J. Armache

This study characterizes the catalytic and non-catalytic mechanisms of SUV420H1 by determining cryo-EM structures and showing its role in DNA accessibility and chromatin condensation.

bioRxiv · Mar 17, 2023Biochemistry

Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1

J. F. Thomas, M. I. Valencia-Sanchez, S. Tamburri, S. L. Gloor, S. Rustichelli, V. Godinez-Lopez, P. De Ioannes, R. Lee, S. Abini-Agbomson, K. Gretarsson, J. M. Burg, A. R. Hickman, L. Sun, S. Gopinath, H. Taylor, , K.-J. Armache

This study reveals the molecular mechanism of nucleosomal H2AK119Ub deubiquitination by human BAP1/ASXL1 and explains how cancer mutations disrupt this process.

bioRxiv · Feb 23, 2023Biochemistry

Shelterin is a Dimeric Complex with Extensive Structural Heterogeneity

J. C. Zinder, P. D. B. Olinares, V. Svetlov, M. W. Bush, E. Nudler, B. T. Chait, T. Walz, T. de Lange

This study characterizes the structural architecture and conformational variability of the human shelterin complex using multiple biophysical methods.

bioRxiv · Jan 24, 2022Biochemistry

Cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state

S. W. Cai, J. C. Zinder, V. Svetlov, M. Bush, E. Nudler, T. Walz, T. de Lange

The paper presents a cryo-EM structure of the human CST·Polα/Primase complex in a recruitment state, revealing its architecture and informing on disease mutations.

bioRxiv · Dec 17, 2021Biochemistry