Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies
R. Jeger-Madiot, D. Planas, I. Staropoli, J. Kervevan, H. Mary, C. Collina, B. F. Fonseca, H. Debarnot, R. Robinot, S. Gellenoncourt, O. Schwartz, L. Ewart, M. Bscheider, S. Gobaa, L. A. Chakrabarti
The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.
bioRxiv · Feb 2, 2024 · PreprintImmunology