Author

D. Planas

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 9 Immunology· 7 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 17 Research Focus:host-pathogen & immune response· 16 Organism:human· 11 Assay:proteomics· 7 Organism:virus· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

O. Schwartz· 14 shared C. Planchais· 10 shared H. Mouquet· 10 shared F. Porrot· 9 shared I. Staropoli· 9 shared T. Bruel· 9 shared F. Guivel-Benhassine· 8 shared E. Simon-Loriere· 7 shared

Activity by Year

2020-2024 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

14 shared papersMicrobiology

O. Schwartz

Mutual co-authors in cluster

Author profile →

17 papers

Recent·Most cited

Metformin Enhances Antibody-Mediated Recognition of HIV-Infected CD4+ T-Cells by Decreasing Viral Release

A. Fert, J. Richard, L. Raymond Marchand, D. Planas, J.-P. Routy, N. Chomont, A. Finzi, P. Ancuta

This study shows metformin reduces HIV-1 virion release and increases antibody recognition of infected CD4+ T-cells by modulating BST2 and Bcl-2 expression in HIV-positive individuals on ART.

bioRxiv · Feb 15, 2024 · PreprintImmunology

Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

R. Jeger-Madiot, D. Planas, I. Staropoli, J. Kervevan, H. Mary, C. Collina, B. F. Fonseca, H. Debarnot, R. Robinot, S. Gellenoncourt, O. Schwartz, L. Ewart, M. Bscheider, S. Gobaa, L. A. Chakrabarti

The paper develops a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies by mimicking immune responses to SARS-CoV-2 Spike protein and comparing monovalent and bivalent vaccines.

bioRxiv · Feb 2, 2024 · PreprintImmunology

Distinct evolution of SARS-CoV-2 Omicron XBB and BA.2.86/JN.1 lineages combining increased fitness and antibody evasion

D. Planas, I. Staropoli, V. Michel, F. Lemoine, F. Donati, M. Prot, F. Porrot, F. G. Benhassine, B. Jeyarajah, A. Brisebarre, O. Dehan, L. Avon, W. Bolland, M. Hubert, J. Buchreiser, , O. Schwartz

This study characterizes SARS-CoV-2 variants XBB and BA.2.86/JN.1, finding they show increased fitness and antibody evasion while maintaining antiviral sensitivity.

bioRxiv · Nov 20, 2023 · PreprintMicrobiology

Neutralisation of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies induced by earlier infection or vaccination

R. Lassauniere, C. Polacek, S. Baig, K. Ellegaard, L. A. Escobar-Herrera, A. Fomsgaard, K. Spiess, O. Schwartz, D. Planas, E. Simon-Loriere, U. V. Schneider, R. N. Sieber, M. Stegger, T. G. Krause, H. Ullum, , M. Rasmussen

The paper assesses the neutralization of SARS-CoV-2 Omicron subvariants BA.2.86 and EG.5.1 by antibodies from prior infection or vaccination, finding comparable neutralization titres to XBB.1 and EG.5.1.

bioRxiv · Oct 1, 2023 · PreprintImmunology

High fusion and cytopathy of SARS-CoV-2 variant B.1.640.1

W. Bolland, V. Michel, D. Planas, M. Hubert, F. Guivel-Benhassine, F. Porrot, I. Staropoli, M. N'Debi, C. Rodriguez, S. Fourati, M. Prot, C. Planchais, L. Hocqueloux, E. Simon-Loriere, H. Mouquet, , J. Buchrieser

This study characterizes the high fusogenicity and cytopathic effects of the SARS-CoV-2 B.1.640.1 variant, identifying mutations in the spike S2 domain responsible for these properties.

bioRxiv · Sep 6, 2023Microbiology

Experimental testing of two urban stressors on freshwater biofilms

R. Vrba, I. Lavoie, N. Creusot, M. Eon, D. Millan-Navarro, A. Feurtet-Mazel, N. Mazzella, A. Moreira, D. Planas, S. Morin

This study examines the individual and combined effects of DDBAC and ALAN on freshwater biofilms, finding DDBAC significantly reduces photosynthetic activity and alters biofilm composition, while ALAN does not significantly interact with DDBAC.

bioRxiv · Jun 11, 2023Ecology

Resistance of Omicron subvariants BA.2.75.2, BA.4.6 and BQ.1.1 to neutralizing antibodies

D. Planas, T. Bruel, I. Staropoli, F. Guivel-Benhassine, F. Porrot, P. Maes, L. Grzelak, M. Prot, S. Mougari, C. Planchais, J. Puech, M. Saliba, R. Sahraoui, F. Femy, N. Morel, , O. Schwartz

This study evaluates the neutralizing antibody resistance of SARS-CoV-2 Omicron subvariants BA.2.75.2, BA.4.6, and BQ.1.1 to monoclonal antibodies and sera from vaccinated individuals.

bioRxiv · Nov 17, 2022Microbiology

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

J. L. Torres, G. Ozorowski, E. Andreano, H. Liu, J. Copps, G. Piccini, L. Donnici, M. Conti, C. Planchais, D. Planas, N. Manganaro, E. Pantano, I. Paciello, P. Pileri, T. Bruel, , A. B. Ward

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

Proceedings of the National Academy of Sciences · May 12, 2022Peer-reviewedImmunology

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

N. Saunders, D. Planas, W. H. Bolland, C. Rodriguez, S. Fourati, J. Buchrieser, C. Planchais, M. Prot, I. Staropoli, F. Guivel-Benhassine, F. Porrot, D. Veyer, H. Pere, N. Robillard, M. Saliba, , O. Schwartz

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

bioRxiv · Jan 7, 2022Microbiology

Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization

D. Planas, N. Saunders, P. Maes, F. G. Benhassine, C. Planchais, F. Porrot, I. Staropoli, F. Lemoine, H. Pere, D. Veyer, J. Puech, J. Rodary, W. H. Bolland, J. Buchrieser, G. Baele, , O. Schwartz

This study shows that the Omicron variant of SARS-CoV-2 is resistant to most monoclonal antibodies and vaccine-induced antibodies, with reduced neutralization compared to Delta.

bioRxiv · Dec 14, 2021Immunology

SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation

M. M. Rajah, M. Hubert, E. Bishop, N. Saunders, R. Robinot, L. Grzelak, D. Planas, J. Dufloo, S. Gellenoncourt, A. Bongers, M. Zivaljic, C. Planchais, F. Guivel-Benhassine, F. Porrot, H. Mouquet, , O. Schwartz

This study compares syncytia formation by SARS-CoV-2 Alpha, Beta, and Delta variants to D614G, finding enhanced fusogenicity and differential effects of mutations on ACE2 binding and antibody escape.

bioRxiv · Jun 11, 2021Microbiology

Species-specific molecular barriers to SARS-CoV-2 replication in bat cells

S.-M. Aicher, F. Streicher, M. Chazal, D. Planas, D. Luo, J. Buchrieser, M. Nemcova, V. Seidlova, J. Zukal, J. Serra-Cobo, D. Pontier, O. Schwartz, J. Pikula, L. Dacheux, N. Jouvenet

The paper investigates SARS-CoV-2 replication in bat cells and finds species-specific molecular barriers, with some cells controlling viral replication after human ACE2 expression.

bioRxiv · May 31, 2021Microbiology

Reduced sensitivity of infectious SARS-CoV-2 variant B.1.617.2 to monoclonal antibodies and sera from convalescent and vaccinated individuals

D. Planas, D. Veyer, A. Baidaliuk, I. Staropoli, F. Guivel-Benhassine, M. Rajah, C. Planchais, F. Porrot, N. Robillard, J. Puech, M. Prot, F. Gallais, P. Gantner, A. Velay, J. Le Guen, , O. Schwartz

This study shows that the SARS-CoV-2 B.1.617.2 variant is less sensitive to monoclonal antibodies and sera from convalescent and vaccinated individuals compared to other variants.

bioRxiv · May 26, 2021 · PreprintMicrobiology

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

T. R. Wiche Salinas, Y. Zhang, D. Sarnello, A. Zhyvoloup, L. Raymond-Marchand, D. Planas, M. Lodha, D. Chatterjee, K. Karwacz, S. Oxenford, J.-P. Routy, H. Amrine-Madsen, P. Ancuta, A. Fassati

This paper identifies RORC2 as a key host factor that promotes HIV-1 gene expression and viral outgrowth in Th17 cells, suggesting it as a new therapeutic target.

bioRxiv · Mar 27, 2021Microbiology

Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies

D. Planas, T. Bruel, L. Grzelak, F. Guivel-Benhassine, I. Staropoli, F. Porrot, C. Planchais, J. Buchrieser, M. M. Rajah, E. Bishop, M. Albert, F. Donati, S. Behillil, V. Enouf, M. Marianne, , O. Schwartz

This study assesses the neutralization sensitivity of SARS-CoV-2 B.1.1.7 and B.1.351 variants compared to D614G using sera and nasal swabs, finding reduced efficacy against B.1.351 in some convalescent and vaccinated individuals.

bioRxiv · Feb 12, 2021 · PreprintImmunology

Syncytia formation by SARS-CoV-2 infected cells

J. Buchrieser, J. Dufloo, M. Hubert, B. Monel, D. Planas, M. M. Rajah, C. Planchais, F. Porrot, F. Guivel-Benhassine, S. van der Werf, N. Casartelli, H. Mouquet, T. Bruel, O. Schwartz

This study shows SARS-CoV-2 infected cells form syncytia via Spike protein-mediated fusion, regulated by IFITMs and TMPRSS2.

The EMBO Journal · Nov 4, 2020Peer-reviewedMicrobiology