Author

J. Sam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

C. Klein· 2 shared M. Bacac· 2 shared A. B. Roth· 1 shared A. Freimoser-Grundschober· 1 shared A. M. Giusti· 1 shared A. Moisan· 1 shared A. Schneider· 1 shared A. Varol· 1 shared

Activity by Year

2017-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

C. Klein

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Human immunocompetent Organs-on-Chips platforms allow safety profiling of tumor-targeted T-cell bispecific antibodies

L. Cabon, D. Petropolis, W. Tien-Street, P. R. Ng, H. S. Grant, K. Karalis, G. A. Hamilton, J. Sam, T. Weinzierl, T. Fauti, A. Freimoser-Grundschober, J. Eckmann, C. Hage, M. Geiger, V. Micallef, , R. Barrile

The paper demonstrates that human immunocompetent Organs-on-Chips can predict safety liabilities of T-cell bispecific antibodies targeting tumor antigens.

bioRxiv · Feb 22, 2021Cancer Biology

Cross-Linking of T cell to B cell lymphoma by the T cell bispecific antibody CD20-TCB induces IFNγ/CXCL10-dependent peripheral T cell recruitment in humanized murine model.

F. Cremasco, E. Menietti, D. Speziale, J. Sam, S. Sammicheli, M. Richard, A. Varol, C. Klein, P. Umana, M. Bacac, S. Colombetti, M. Perro

This study investigates how CD20-TCB induces T cell-tumor synapses and recruitment in a humanized murine model of DLBCL, revealing a triple mechanism involving synapse formation, resident T cell proliferation, and peripheral T cell recruitment.

bioRxiv · Oct 9, 2020Immunology

The integrated stress response pathway activates 4E-BP to bias mRNA translation and boost antimicrobial peptide synthesis in response to bacterial infection

D. Vasudevan, N. Clark, J. Sam, B. Ueberheide, M. T. Marr, H. D. Ryoo

This study shows that 4E-BP, induced by GCN2/ATF4 during bacterial infection, promotes cap-independent translation of antimicrobial peptides in Drosophila.

bioRxiv · Jun 8, 2017Immunology