'Off-pore' nucleoporins relocalize heterochromatic breaks through phase separation
C. Merigliano, T. Ryu, C. D. See, C. P. Caridi, X. Li, N. Butova, T. Reynolds, C. Deng, D. M. Chenoweth, M. Capelson, I. Chiolo
The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.
bioRxiv · Dec 7, 2023 · PreprintCell Biology