D. M. Chenoweth

SUMO Promotes DNA Repair Protein Collaboration to Support Alterative Telomere Lengthening in the Absence of PML

This study shows SUMO promotes DNA repair protein collaboration for telomere maintenance in ALT cancer cells without PML bodies.

'Off-pore' nucleoporins relocalize heterochromatic breaks through phase separation

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

CRISPR Cas13-based tools to track and manipulate endogenous telomeric repeat-containing RNAs in living cells

This study develops CRISPR Cas13 and Suntag tools to track and manipulate TERRA in live cells, revealing its anomalous diffusion and subcellular localization dynamics.

Tension promotes kinetochore-microtubule release in response to Aurora B activity

The paper shows that Aurora B kinase activity leads to kinetochore-microtubule release under high tension and depolymerization under low tension, suggesting tension-dependent error correction mechanisms.

Liquid condensation drives telomere clustering during ALT

The paper shows that APBs function as liquid condensates that cluster telomeres through liquid properties, supporting the ALT pathway in telomerase-free cancer cells.

Spindle asymmetry drives non-Mendelian chromosome segregation

The paper shows that spindle asymmetry, regulated by CDC42 signaling and microtubule tyrosination, enables non-Mendelian chromosome segregation during female meiosis.