C. Deng

A critical role of protein damage response in mediating cancer drug resistance

This study identifies protein damage response (PDR) as a key mechanism in cancer drug resistance, showing that targeting PDR components can enhance drug efficacy in resistant cells.

A standalone reverse dissimilatory sulfite reductase (rDsr) pathway enables sulfur oxidation under oxygen limitation

This study shows that the reverse dissimilatory sulfite reductase (rDsr) pathway can independently oxidize thiosulfate under low oxygen conditions, supporting its ecological role in marine sediments.

Cell Competition Eliminates Aneuploid Human Pluripotent Stem Cells

The paper shows that aneuploid human pluripotent stem cells are outcompeted by diploid cells through Myc and p53-driven cell competition, preserving genome stability.

A conserved lysine/arginine-rich motif in potyviral 6K1 protein is key in engaging autophagy-mediated self-degradation for completing pepper veinal mottle virus infection

This study identifies a conserved lysine/arginine-rich motif in potyviral 6K1 protein that mediates autophagy-mediated self-degradation, essential for viral infection.

TLR9 activation in large wound induces tissue repair and hair follicle regeneration via gamma delta T cells

This study shows that TLR9 activation in wounds promotes tissue repair and hair follicle regeneration through gamma delta T cells by increasing AREG production and modulating keratinocyte fate.

'Off-pore' nucleoporins relocalize heterochromatic breaks through phase separation

The paper shows that Nup98 nucleoporins use phase separation to mobilize heterochromatic repair sites and exclude Rad51, promoting homologous recombination and genome integrity.

Nitrite deteriorates bioreactor performance by reducing growth of Ca. Brocadia sapporoensis instead of inhibiting the anammox activity

This study shows that nitrite reduces the growth of Ca. Brocadia sapporoensis in anammox systems, leading to performance collapse, rather than directly inhibiting anammox activity.

The Application of Label-free Detection Using a Tapered Optical Fiber System for Head and Neck Cancer and Infectious Biomolecules

This paper demonstrates a tapered optical fiber sensor capable of detecting biomolecules like IL-8 and HCoV-OC43 with high sensitivity and specificity.

circDesign Algorithm for Designing Synthetic Circular RNA

This paper introduces circDesign, an algorithm for designing synthetic circular RNA that improves stability and protein translation efficiency, demonstrated using rabies virus glycoprotein.

Systematic Approach Identifies Multiple Transcription Factor Perturbations That Rejuvenate Replicatively Aged Human Skin Fibroblasts

The paper identifies multiple transcription factor perturbations that rejuvenate aged human skin fibroblasts through a Perturb-seq screen and validation of aging hallmarks.

Three-dimensional genome re-wiring in loci with Human Accelerated Regions

The paper identifies human-specific 3D genome re-wiring in conserved loci, linking accelerated evolution to regulatory rewiring in neural progenitor cells.

A SHR-IDD-PIN regulatory network mediates minor vein differentiation in rice

The paper identifies a SHR-IDD-PIN regulatory network that controls minor vein differentiation in rice and C4 grasses by regulating auxin flow through PIN protein expression.

Delivery of Circular mRNA via Degradable Lipid Nanoparticles against SARS-COV-2 Delta Variant

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

A Pluripotent Developmental State Confers a Low Fidelity of Chromosome Segregation

This study identifies lagging chromosomes with improper merotelic attachments as the primary cause of mitotic errors in human pluripotent stem cells and shows that these errors correlate with developmental potential.

Assessment of chimeric antigen receptor T (CAR-T) cytotoxicity by droplet microfluidics in vitro

This study presents a droplet microfluidic assay to assess CAR-T cytotoxicity in vitro, enabling analysis of activity, expansion, and mechanism under varying conditions.

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

Knowledge and Awareness of coronavirus disease 2019 (COVID-19) among Chinese dental students----a comparison study.

This study compares knowledge and awareness of COVID-19 between Chinese dental students and nonmedical students, finding dental students scored higher overall but had weaknesses in treatment and prevention.

CK1 Delta Is an mRNA Cap-Associated Protein That Drives Translation Initiation and Tumor Growth

This paper identifies CK1 delta as an mRNA cap-associated protein that drives translation initiation and tumor growth in blood cancers, with distinct roles in solid tumors.

PRDM3 attenuates pancreatitis and pancreatic tumorigenesis by regulating inflammatory response

This study shows PRDM3 suppresses pancreatitis and pancreatic tumorigenesis by modulating inflammation and Kras-driven oncogenesis in acinar cells.

Dissecting the dilemma between in vitro and in vivo drug screening: treating HepG2 cells with Artesunate as a model

This study compares in vitro and in vivo drug responses to Artesunate in HepG2 cells, finding discrepancies in efficacy and biomarker expression.

Multiple quantitative trait loci contribute tolerance to bacterial canker incited by Pseudomonas syringae pv. actinidiae in kiwifruit (Actinidia chinensis)

This study identifies multiple quantitative trait loci (QTLs) associated with tolerance to Pseudomonas syringae pv. actinidiae in kiwifruit, revealing genetic pathways involved in resistance.

ARID1a protects against steatosis and insulin resistance via PPARalpha-mediated fatty acid oxidation

This study shows that Arid1a deficiency in mice leads to hepatic steatosis and insulin resistance by impairing fatty acid oxidation through PPARalpha.