Author

M. Capula

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:proteomics· 1

Frequent Co-Authors

E. Giovannetti· 3 shared T. Schmidt· 3 shared A. Gregori· 2 shared C. Bergonzini· 2 shared E. H. J. Danen· 2 shared A. Botto· 1 shared A. J. M. Zweemer· 1 shared B. van de Water· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiophysics

E. Giovannetti

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and Paclitaxel.

A. Gregori, C. Bergonzini, M. Capula, R. Rodrigues de Mercado, E. H. J. Danen, E. Giovannetti, T. Schmidt

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.

bioRxiv · Apr 10, 2024Biophysics

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

C. Bergonzini, A. Gregori, T. M. S. Hagens, V. E. van der Noord, B. van de Water, A. J. M. Zweemer, M. Capula, G. Mantini, A. Botto, F. Finamore, I. Garajova, L. A. McDonnell, T. Schmidt, E. Giovannetti, E. H. J. Danen

This study identifies ABCB1 overexpression via locus amplification as a conserved mechanism of paclitaxel resistance in PDAC and shows that targeting ABCB1 can sensitize resistant cells to treatment.

bioRxiv · May 30, 2023 · PreprintCancer Biology

A mechanical memory of pancreatic cancer cells

I. Carnevale, M. Capula, E. Giovannetti, T. Schmidt, S. Coppola

This study shows pancreatic cancer cells retain mechanical memory of past matrix stiffness, mediated by YAP and miR-21, which affects drug resistance.

bioRxiv · Aug 9, 2019 · PreprintBiophysics