E. Giovannetti

Acclimation of photosynthesis began with a Cu-binding superoxide detoxifying enzyme

The paper identifies APE1 as a Cu-binding superoxide detoxifying enzyme essential for photosynthetic acclimation to oxygenic environments.

Altered Mechanobiology of PDAC Cells with Acquired Chemoresistance to Gemcitabine and Paclitaxel.

This study investigates altered mechanobiology in PDAC cells with acquired chemoresistance to gemcitabine and paclitaxel, finding increased traction forces and altered motility and invasion.

Large pan-cancer cell screen coupled to (phospho-) proteomics underscores high-dose vitamin C as a potent anti-cancer agent

This study evaluates high-dose vitamin C's anti-cancer effects across 51 cancer cell lines, finding high sensitivity and proteomic changes linked to cell cycle and immune pathways.

ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells

This study identifies ABCB1 overexpression via locus amplification as a conserved mechanism of paclitaxel resistance in PDAC and shows that targeting ABCB1 can sensitize resistant cells to treatment.

A mechanical memory of pancreatic cancer cells

This study shows pancreatic cancer cells retain mechanical memory of past matrix stiffness, mediated by YAP and miR-21, which affects drug resistance.