Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer
B. J. Sishc, J. Saha, E. Polsdofer, L. Ding, H. Lu, S.-Y. Wang, K. L. Swancutt, J. H. Nicholson, A. Facoetti, A. Pompos, M. Ciocca, T. A. Aguilera, M. D. Story, A. J. Davis
This study identifies PDAC cell lines defective in homologous recombination or with high genomic instability as more responsive to carbon ion radiotherapy, suggesting potential for targeted therapy.
bioRxiv · Apr 8, 2024Cancer Biology